PROLONGED IMMUNE-INFLAMMATORY REACTIONS IN PATIENTS WITH COVID-19- ASSOCIATED SURGICAL PATHOLOGY IN THE POSTCOVID PERIOD

Summary. Introduction. The combination of pathogenetic factors the main surgical pathology, multiple organ dysfunction, acute respiratory distress syndrome and cytokine storm against background SARS-Cov-2 infection justifies relevance this study.
 Materials methods. We examined 13 patients with COVID-19 29 SARS-Cov-2-associated urgent pathology. Investigated concentration C-reactive protein (CRP) by latex agglutination, C3 C4 components complement immunoturbidimetry, content interleukins IL-6 IL-18 ELISA, determination autoantibodies luminescence microscopy.
 Results. In certain patterns changes in markers under study were revealed: all groups patients, an increased was observed, which indicated a systemic inflammatory response both postcovid period. period viral infection, most significant are high frequency maximum increase CRP, C3- C4-complement components, or moderate IL-18, more pronounced than infection. pro-inflammatory cytokines found abdominal pathology (postcoid period), while COVID-19, had no diagnostic value. A detected 20.5% COVID-19-associated pathology.
 Conclusions. For formation autoimmune conditions is characteristic, expressed presence wide range to nuclear structures. Thus, for prevention complex treatment it advisable use personified step-by-step immunotropic therapy.